Barbiturates can induce hepatic microsomal enzymes leading to elevated metabolism and diminished anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); sufferers stabilized on anticoagulant therapy may call for dosage changes if barbiturates are added to or withdrawn from their dosage routine
fentanyl iontophoretic transdermal procedure and pentobarbital both equally increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternate treatment solutions are inadequate
fentanyl transmucosal and pentobarbital both equally enhance sedation. Steer clear of or Use Alternate Drug. Restrict use to sufferers for whom alternative treatment selections are inadequate
buprenorphine transdermal and pentobarbital each improve sedation. Stay clear of or Use Alternate Drug. Restrict use to people for whom alternate treatment method possibilities are inadequate
pentobarbital will reduce the extent or impact of losartan by influencing hepatic enzyme CYP2C9/10 metabolism. Insignificant/Importance Unknown.
pentobarbital will reduce the level or impact of nisoldipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
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Ordering drug ranges inside the blood or urine, acceptable laboratory assessments, and imaging while in the unexpected emergency Division.
pentobarbital will lower the level or result of carvedilol by influencing hepatic enzyme CYP2C9/10 metabolism. Use Caution/Keep an eye on.
pentobarbital decreases amounts of elvitegravir/cobicistat/emtricitabine/tenofovir DF by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May possibly result in lack of virologic response and attainable resistance.
pentobarbital will lower the extent or result of fosphenytoin by affecting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Keep track of.
pentobarbital will increase toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers may possibly enhance the metabolism of ifosfamide to its active alkylating metabolites.
Coadministration of zuranolone with other CNS depressants may well improve impairment of psychomotor performance or CNS depressant results. If unavoidable, consider dose reduction. .
pentobarbital will lessen the level or result of dasatinib by here influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.